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Parasitic helminths [electronic resource] : targets, screens, drugs and vaccines /

edited by Conor R. Caffrey.

Book Cover
Names: Caffrey, Conor R.
Published: Weinheim, Germany : Wiley-VCH, 2012.
Series: Drug discovery in infectious diseases ; v. 3.
Topics: Helminths. | Parasites. | Parasitic diseases - Treatment. | Parasitic diseases - Diagnosis.
Genres: Electronic books.
Online Access: Wiley Online Library - Full text
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245 00|aParasitic helminths|h[electronic resource] :|btargets, screens, drugs and vaccines /|cedited by Conor R. Caffrey.
260 |aWeinheim, Germany :|bWiley-VCH,|c2012.
300 |a1 online resource (xxiii, 516 pages) :|billustrations (some color).
336 |atext|btxt|2rdacontent
337 |acomputer|bc|2rdamedia
338 |aonline resource|bcr|2rdacarrier
490 1 |aDrug discovery in infectious diseases ;|vv. 3
504 |aIncludes bibliographical references and index.
505 0 |aPart one: targets -- Ligand-gated ion channels as targets for anthelmintic drugs: past, current, and future perspectives -- How relevant is Caenorhabditis elegans as a model for the analysis of parasitic nematode biology? -- Integrating and mining helminth genomes to discover and prioritize novel therapeutic targets -- Recent progress in transcriptomics of key gastrointestinal nematodes of animals: fundamental research toward new intervention strategies -- Harnessing genomic technologies to explore the molecular biology of liver flukes-major implications for fundamental and applied research -- RNA interference: a potential discovery tool for therapeutic targets of parasitic nematodes -- RNA interference as a tool for drug discovery in parasitic flatworms -- Part two: screens -- Mechanism-based screening strategies for anthelmintic discovery -- Identification and profiling of nematicidal compounds in veterinary parasitology -- Quantitative high-content screening-based drug discovery against helmintic diseases -- Use of rodent models in the discovery of novel anthelmintics -- To kill a mocking worm: strategies to improve Caenorhabditis elegans as a model system for use in anthelmintic discovery -- Part three: drugs -- Anthelmintic drugs: tools and shortcuts for the long road from discovery to product -- Antinematodal drugs: modes of action and resistance: and worms will not come to thee (Shakespeare: Cymbeline: iv, ii) -- Drugs and targets to perturb the symbiosis of Wolbachia and filarial nematodes -- Promise of Bacillus thuringiensis crystal proteins as anthelmintics -- Monepantel: from discovery to mode of action -- Discovery, mode of action, and commercialization of derquantel -- Praziquantel: too good to be replaced? -- Drug discovery for trematodiases: challenges and progress -- Part four: vaccines -- Barefoot thru' the valley of darkness: preclinical development of a human hookworm vaccine -- Vaccines linked to chemotherapy: a new approach to control helminth infections -- Antifilarial vaccine development: present and future approaches -- Proteases as vaccines against gastrointestinal nematode parasites of sheep and cattle -- Schistosomiasis vaccines: new approaches to antigen discovery and promising new candidates -- Sm14 Schistosoma mansoni fatty acid-binding protein: molecular basis for an antihelminth vaccine -- Mechanisms of immune modulation by Fasciola hepatica: importance for vaccine development and for novel immunotherapeutics -- Prospects for immunoprophylaxis against Fasciola hepatica (liver fluke) -- Vaccines against cestode parasites.
650 0|aHelminths.
650 0|aParasites.
650 0|aParasitic diseases|xTreatment.
650 0|aParasitic diseases|xDiagnosis.
650 7|aHelminths.|2fast|0(OCoLC)fst00954813
650 7|aParasites.|2fast|0(OCoLC)fst01053134
650 7|aParasitic diseases|xDiagnosis.|2fast|0(OCoLC)fst01053153
650 7|aParasitic diseases|xTreatment.|2fast|0(OCoLC)fst01053167
655 4|aElectronic books.
700 1 |aCaffrey, Conor R.
830 0|aDrug discovery in infectious diseases ;|vv. 3.
856 40|3Wiley Online Library - Full text|uhttp://www.library.uiuc.edu/proxy/go.php?url=http://dx.doi.org/10.1002/9783527652969|xUIU
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938 |aYBP Library Services|bYANK|n8857278
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Staff View for: Parasitic helminths : targets, screens,